![]() J Appl Physiol 57: 1809 1816Įgan EA, Nelson RM, Olver RE (1976) Lung inflation and alveolar permeability to non-electrolytes in the adult sheep in vivo. Parker JC, Townsley MI, Rippe B, Taylor AE, Thigpen 1 (1984) Increased microvascular permeability in dog lungs due to high peak airway pressures. Tsuno K, Prato P, Kolobow T (1990) Acute lung injury from mechanical ventilation at moderately high airway pressures. Kolobow T, Moretti MP, Fumagalli R, Mascheroni D, Prato P, Chen V, Joris M (1987) Severe impairment in lung function induced by high peak airway pressure during mechanical ventilation. Protection by positive end-expiratory pressure. Webb HH, Tierney DF (1974) Experimental pulmonary edema due to intermittent positive pressure ventilation. Pingleton SK (1988) Complications of acute respiratory failure. This process is experimental and the keywords may be updated as the learning algorithm improves. These keywords were added by machine and not by the authors. These abnormalities may culminate in the production of a pulmonary permeability-type edema accompanied by diffuse alveolar damage. In addition to these “macroscopic” alterations, it has been experimentally demonstrated that lung distension during mechanical ventilation may induce alterations of lung fluid balance, increases in endothelial and epithelial permeability and severe ultrastructural damage. ![]() ![]() Barotrauma is the usual term for such complications and refers to the presence of extra-alveolar air (manifesting as interstitial emphysema, pneumomediastinum or pneumoperitoneum, pneumothorax, etc.). Of these adverse effects, some are the direct consequence of pulmonary pressure and/or volume changes induced by mechanical insufflation of diseased lungs. Mechanical ventilation is a technique which, although frequently life-saving, carries nevertheless the potential risk of severe complications.
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